NIH R01 · 2025
Mechanisms of STAT1 and STAT3 canonical and persistent activation in physiology and disease
Summary Rapid plasma membrane-to-nucleus relocalization of Signal Transducer and Activator of Transcription (STAT) family members upon cytokines stimulation is vital for signal transduction. Countless cell processes, including immune cell’s ability to fight pathogens, depend directly on STAT signaling. Extracellular signals typically result in STAT phosphorylation, triggering a conformational change that leads to importin recruitment and nuclear translocation. In the nucleus, STATs function as transcription factors, inducing the expression of a plethora of genes involved in native immunity, survival, cell growth, proliferation, and pathogen response. Gain-of-function (GOF) mutations in…
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