NIH R01 · 2024
Combining modeling and experiments to study the evolution of cells with altered ploidy
Project Summary Aneuploidy is a ubiquitous feature of cancer cells, and accumulation of aneuploidy is believed to often happen via tetraploidization (genome doubling) as an intermediate step. This idea is based on the observations that nearly 40% of all tumors have likely undergone whole genome duplication during their clonal evolution, that tetraploidy was shown to buffer chromosomal instability (CIN), and that tetraploid (4N), but not diploid (2N), mammary epithelial cells could induce subcutaneous tumors in nude mice. A widely accepted model suggests that the extra centrosomes commonly arising during tetraploidization are responsible for ongoing chromosome missegregation during mitosis…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.