NIH R01 · 2025
Regulation of DNA synthesis in response to DNA damage
PROJECT SUMMARY Genomic DNA is constantly challenged by DNA damage either spontaneously induced during cellular metabolism or generated by exogenous DNA damaging agents. During DNA replication, DNA lesions can cause the stalling or collapse of replication forks. Fork collapse results in the formation of DNA double-strand breaks (DSBs). MCM8 and MCM9 (MCM8-9) form a helicase complex that promotes the repair of DSBs by homologous recombination. We recently identified MCM8IP as a novel interactor of MCM8-9 that maintains genomic integrity after replication stress. In particular, we showed that MCM8IP promotes DSB repair by homologous recombination, facilitates the restart of replication forks…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.