Ciccarone Lab

University of California, San Francisco

FAMILY MEDICINE

San Francisco · United States

NIH-funded
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NIH R01 · 2025

Synthetics in Combination (SYNC)

Summary Over the last decade fentanyls, methamphetamine and benzodiazepines have proliferated in US illicit drug markets. These synthetic drugs, increasingly in combinations, are implicated in the ongoing rise in overdose fatalities. Although drug overdoses commonly involve more than one substance, polydrug use has long been understudied. Now, the replacement of heroin with novel synthetics such as fentanyls, the resurgence of methamphetamine, and the proliferation of counterfeit pills, have created a situation of new complexity and unknown risks with an urgent need for knowledge. People who use drugs are creating new patterns and modes of polydrug use, for which their motives and…

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