NIH R01 · 2025
Determining the Molecular Basis for HIV-1 Retrograde Trafficking
PROJECT SUMMARY During HIV-1 infection, the viral membrane fuses with the host cell membrane to deliver the HIV-1 virus to the host cell cytoplasm. Once within the host cell, HIV-1 must move to the nucleus so that the viral DNA generated by reverse transcription can be incorporated into the host genome. The host microtubule network and the microtubule-associated motor dynein support infection by facilitating HIV-1 transport to the nucleus. This proposal aims to determine how HIV-1 exploits the dynein machinery during transit to the nucleus. Dynein cannot walk on microtubules unless bound to a class of proteins called adaptors. In addition to activating dynein, adaptors also link dynein to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.