NIH R01 · 2025
Global control of co-transcriptional splicing
Project Summary Alternative splicing (AS) is a widespread phenomenon in human genes that significantly diversifies the types of proteins and RNAs produced. This process plays an essential role in defining cellular differentiation and identity3,4. Moreover, problems in alternative splicing have been directly linked to a range of human diseases such as muscular dystrophies, neurodegenerative conditions, and cancers. The typical human gene has about eight introns, which are processed by spliceosomal subunits that recognize sequences near splice sites (SSs) and branchpoints. During the splicing process, AS arises as the result of kinetic competition between multiple possible splicing outcomes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.