NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT The overall goal of this research is to understand how stress disrupts the ovarian cycle. Chronic undernutrition is a type of metabolic stress that impairs reproduction across species, and in women is implicated in the development of functional hypothalamic amenorrhea, an anovulatory disorder resulting from inadequate gonadotropin secretion. Although the tight coupling of energy balance to reproductive capacity is recognized in principle, the neuroendocrine loci and molecular mechanisms that mediate ovarian cycle dysfunction during undernutrition remain poorly understood. In females, ovulatory cyclicity is dependent on two populations of kisspeptin (Kiss1) neurons…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.