NIH R01 · 2024
Epigenetic Regulation of Skin Regional Specificity
Summary (30 lines) The long-term objective of our research is to understand the basic principles regulating the development and regeneration of skin and its appendages, and to apply this knowledge to regenerative medicine. Recent progress in stem cell biology has allowed the production of skin substitutes which help patients suffering from severe skin injuries to survive. Yet, these skin substitutes lack regional specificities seen in human skin (e.g., scalp, face, palm, sole). The next major challenge will be to produce skins with proper region-specific phenotypes for optimal function. While studies on region-specific skin in the mouse ear, sole and human fibroblasts were carried out, no…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.