Barnard Lab

Cleveland Clinic Lerner Com-Cwru

OTHER BASIC SCIENCES

Cleveland · United States

NIH-funded
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NIH R01 · 2024

RADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATION

PROJECT SUMMARY Although ablation to isolate pulmonary vein (PV) triggers has revolutionized atrial fibrillation (AF) management, performing effective AF ablation remains challenging. The procedure remains limited by targeting of ill-defined substrates, a 2-6% risk of major complications and limited success (single procedure 5-year success as low as 17-56%; 63-81% after the last ablation). A major recommendation of a recent NHLBI-sponsored report on the research needs and priorities for AF catheter ablation was to study how cardiac structure affects AF ablation success. There is a clear unmet need for non-invasive imaging tools to aid in improved patient selection, anatomic targeting and…

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