NIH R01 · 2024
CatSper regulation of sperm physiology and fertility
PROJECT SUMMARY Calcium signaling and homeostasis in spermatozoa is essential for successful fertilization. The overall goal of this research program is to elucidate how sperm CatSper channel assembles to form Ca2+ signaling nanodomains and integrates proteolytic and metabolic pathways to control mammalian sperm motility and fertility. The research program aims to understand how calcium signaling and homeostasis in sperm is crucial for suc- cessful fertilization, specifically focusing on the CatSper channel and its crosstalk with other signaling pathways. During the first funding cycle, significant progress has been made in comprehending CatSper's role in sperm motility and fertility.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.