NIH R01 · 2025
Elucidating how long 3'UTRs form and cause autoinflammation
PROJECT SUMMARY The highly dynamic nature of RNA structure is key to diversifying RNA function. Notably, certain RNA structures can act as immunostimulatory molecules. Our immune system uses various pattern recognition receptors (PRRs) to detect immunostimulatory RNA molecules and trigger inflammation. PRRs are present in all immune and non- immune cells ensuring a rapid and broad immune response. Many PRRs are specialized in detecting long double-stranded RNA (dsRNA) structures, classically thought to be present in the viral genome. Interestingly, our studies, as well as the studies of others, have demonstrated that aberrant sensing of endogenous (self) dsRNAs by PRRs can cause severe…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.