NIH R01 · 2025
Ultrasensitive detection of circulating DNA methylation for head and neck cancer prognosis
PROJECT SUMMARY/ ABSTRACT Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent aggressive cancers worldwide. Despite advances in diagnostics and treatments, the 5-year survival of HNSCC remains low (~50%). Patients with HPV-negative tumors exhibited an even worse prognosis. There is a pressing and unmet need to identify reliable molecular biomarkers for prognostic prediction in HNSCC, crucial for personalized patient care. This enables the selection of more aggressive or novel treatments like immunotherapy for high-risk patients, while also guiding treatment deintensification for those at low risk. DNA methylation (DNAme) is a key player in all major cancer hallmarks,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.