NIH R01 · 2024
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7. PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduced and with preserved ejection fraction- and is present in nearly 25% of asymptomatic individuals. Unfortunately, no treatments for impaired relaxation exist. Recently, my lab identified and defined Mechanical Control of Relaxation as a faster relaxation rate in response to the rate of a lengthening strain. In other words, the relaxation rate is sensitive to the strain rate of the myocardium. Our data demonstrate that this mechanical regulation of relaxation can increase the relaxation rate two-fold beyond the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.