NIH R01 · 2024
Enamel with overexpressed ameloblastin
PROJECT SUMMARY/ABSTRACT Molar-Incisor Hypomineralization (MIH) is a highly prevalent in children all around the globe affecting their primary and permanent teeth. The affected enamel has chalky to yellow lesions that are demarcated and less mineralized causing increased caries susceptibility, enamel breakout, esthetic concerns and sensitive teeth. While the treatment and management of these lesions are challenging, the pathophysiology of MIH is not known, hampering the development of a precise, targeted therapy. A striking feature of MIH is the demarcation of defects, such that affected and unaffected enamel are located adjacently, with abrupt changes in mineral density. This feature is in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.