NIH R01 · 2025
PROJECT SUMMARY Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction that affects up to 20% of school children worldwide. Dietary interventions, particularly those removing fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) carbohydrates from the diet, may be helpful in both adults and children with IBS. Unfortunately, there are significant practical and potential health challenges (e.g., unintended weight loss) to following a FODMAP restriction diet. Identifying new therapies beyond dietary restriction alone for FODMAP-induced symptoms, particularly in children, is needed. Fructans are a type of FODMAP that are naturally occurring, abundant in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.