NIH R01 · 2024
Mannose metabolism as a regulator of hepatic stellate cell activation and fibrosis
PROJECT SUMMARY Mannose metabolism as a regulator of hepatic stellate cell activation and fibrosis This proposal addresses the critical unmet need for effective anti-fibrotic therapies by elucidating an unexplored pathway regulating activation of the hepatic stellate cell (HSC), a resident perisinusoidal cell type that stores vitamin A in normal liver. However, among potential mechanisms driving HSC plasticity, sugar metabolism pathways have been largely overlooked. The role of mannose metabolism in HSC biology has not yet been examined, but recent high-impact studies, including ours (Shtraizent and DeRossi et al., eLife 2017), implicate mannose as a mediator of obesity, diabetes, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.