NIH R01 · 2024
Motor cortical circuitry adaptations in experimental Parkinson's disease
PROJECT SUMMARY Parkinson’s disease (PD) is the second most common neurodegenerative disease of aging and as such it associates with a rapidly growing socioeconomic burden. A hallmark of PD is the loss of dopaminergic (DA) neurons in the substantia nigra, which is causally linked to the debilitating motor symptoms that characterize this disease. However, motor function is not confined to the substantia nigra –other brain structures, like the primary motor cortex (M1) that controls specific sets of motor skills, are affected in PD. Until recently, the abnormal activity of M1 neurons observed in PD was thought to be a direct consequence of an increased basal ganglia inhibition due to the loss…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.