NIH R01 · 2024
Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD
Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD PROJECT SUMMARY. Synaptic loss is a major structural correlate of dementia, and reduced spine density is observed in Alzheimer’s disease (AD) and the Lewy body dementia (LBD) disease spectrum. Autosomal recessive mutations in PTEN-induced kinase 1 (PINK1) cause early-onset Parkinson’s disease (PD) and PD with dementia (PDD), with heterozygous carriers exhibiting cognitive-executive dysfunction and cortical degeneration in the absence of motor symptoms. Given that wild type PINK1 is reduced in the cortex of patients with sporadic PDD and AD, we studied the role of endogenous PINK1 in regulating dendritic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.