NIH R01 · 2025
Enteric Glial Mechanotransduction and Mechanical Stress Induced Postoperative Ileus
Despite the implementation of enhanced recovery protocols for gastrointestinal (GI) surgeries (ERAS), there is still significant postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD) associated with prolonged hospitalizations, increased morbidity and health care costs into the billions. A better understanding of the pathogenic mechanism(s) of POI is required to develop better therapeutic strategies. General Hypothesis: Our recent work, strong pilot, feasibility and preliminary data (Figs 1-18) and publications support the novel hypothesis that the glial Piezo-1“mechanosensor” modulates motility, and the mechanical stress’’ on the bowel during GI surgery results in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.