Christodoulou Lab

Research focus

NIH R01 · 2024

Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic Adenocarcinoma

PROJECT SUMMARY Quantitative dynamic contrast enhancement (DCE) MRI metrics such as tissue perfusion rates, kinetic parameters, extravascular volume, and plasma volume allow characterization of subtle differences in tissue states related to ischemia, vascularity, inflammation, and fibrosis in neurological and cardiovascular diseases, and in cancers such as pancreatic adenocardinoma (PDAC). The reproducible nature of quantitative imaging makes it more suitable for multi-center or longitudinal studies than conventional “qualitative” imaging. Quantitative DCE metrics have been shown to be important for risk assessment, early detection, staging, characterization, and treatment monitoring of…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.