NIH R01 · 2024
Structure and Function of Metalloenzymes
The proposed research explores molecular approaches for the study and regulation of aberrant metalloenzyme activity in human disease, focusing on the structural and chemical biology of histone deacetylase (HDAC) isozymes 6, 8, 10, and 11. These zinc-dependent enzymes are targets for drug design efforts aimed at developing new approaches to cancer chemotherapy, treatment of neurodegenerative disease, and immune modulation. To advance our understanding of structure and function in this important family of metalloenzymes, and to enable innovative molecular approaches for new disease therapies, we aim to pursue the following lines of investigation: (1) We propose to determine crystal structures…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.