NIH R01 · 2025
Targeting the NKG2A Pathway in Alopecia Areata
SUMMARY Alopecia Areata (AA) is a chronic autoimmune disease of the hair follicle that results in hair loss. The exact cause of AA is unknown, genetic predisposition and environmental triggers might play important roles in the disease. We previously identified CD8+NKG2D+ T cells as the key pathogenic drivers in AA and our findings led to targeting pathogenic CD8+ T cells through blocking the gamma chain signaling pathway with JAK inhibitors in AA treatment. Recently, we performed single-cell RNA sequencing (scRNAseq) together with single-cell TCR sequencing (scTCRseq), and found that the most highly clonally expanded CD8+NKG2D+ T cells were also positive for the inhibitory receptor, NKG2A.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.