NIH R01 · 2025
Intestinal bacteria and epithelial barrier disruption after alcohol and burn injury
Summary/Abstract Nearly one million burn injuries are reported every year in the United States. Many of these injuries occur under the influence of alcohol intoxication. Intoxication at the time of injury is associated with worse prognosis in burn patients resulting in more adverse outcomes. Gut dysfunction is a common hallmark in post-burn complications and thus studying ways to prevent gut dysfunction following burn injury bears strong clinical relevance. We and others have shown that severe burn or moderate burn injury combined with ethanol exposure disrupts the normal intestinal microbial structure and barrier integrity within 24 hours after injury, but how these changes in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.