NIH R01 · 2025
The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility
Modified Project Summary/Abstract Section Keratinocyte carcinoma (KC), comprised of basal cell carcinoma and squamous cell carcinoma, is the most common malignancy in the United States, afflicting approximately 3 million Americans annually. The treatment of KCs is among the most costly of all cancers. Both basal cell carcinoma and squamous cell carcinoma derive from epidermal keratinocytes, but despite sharing the same cell of origin, these two keratinocyte carcinomas diverge along distinct oncogenic pathways. Risk factors for KCs include innate factors, such as genetic risk loci and fair pigmentation, and environmental exposures, including sun exposure, smoking, and immunosuppression.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.