Choquet Lab

Kaiser Foundation Research Institute

Oakland · United States

NIH-funded
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NIH R01 · 2024

The Role of Genetic and Non-Genetic Factors and Causal Mechanisms Underlying Cataract Susceptibility For Risk Prediction

Abstract Age-related cataract, defined as ocular lens opacity, is a leading cause of blindness worldwide. Cataract is also associated with injurious falls and increased mortality and is a significant public health problem in the U.S., accounting for approximately 60% of Medicare costs related to vision. Given the aging U.S. population, cataract surgery demand is expected to double over the next 25 years. Thus, it is important to understand the etiology of cataract to identify at-risk patients and develop effective prevention strategies. Recently, we conducted a large- scale multiethnic genome-wide association study (GWAS) meta-analysis of cataract that has identified 55 genetic loci,…

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