NIH R01 · 2025
Mechanistic studies on pregnancy-induced humoral sensitization in organ transplantation
Project Abstract Long-term success of transplantation and achieving transplant tolerance in the clinic is hindered by recipient sensitization and immunological memory, which predominantly arise as a result of graft rejection, pregnancy and blood transfusions. Paradoxically, semi-allogeneic pregnancy provides a unique example of allogeneic tolerance spontaneously induced in adults. Using preclinical mouse models, we showed that semi-allogeneic pregnancy simultaneously induces T cell tolerance to the semi-allogeneic fetus and to subsequent offspring-matched heart grafts. However, pregnancy also induces humoral sensitization to fetal antigens, and this sensitization overrides pregnancy-induced…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.