NIH R01 · 2025
Defining the role of GPX3 in Eosinophilic Esophagitis
1 This research proposal investigates the role of Glutathione Peroxidase 3 (GPX3) in regulating 2 esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment, all histologic 3 features characteristic of Eosinophilic Esophagitis (EoE). In order to maintain esophageal 4 epithelial homeostasis, reactive oxygen species (ROS) might be tightly regulated, and GPX3 is 5 crucial in this process as it catalyzes the reduction of ROS. We have demonstrated that in the 6 esophagus, GPX3 is expressed most highly in differentiated epithelial cells but is also expressed 7 by fibroblasts. In patients with EoE, GPX3 is reduced in these same cell types as compared with 8 non-EoE…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.