NIH R01 · 2025
The Impact of Leukocyte-derived Cytokines on Ovulation in Humans
PROJECT SUMMARY/ABSTRACT Mid-cycle gonadotropin-induced ovulation, a pivotal event in female reproductive physiology, shares many features with an acute inflammatory response, notably marked by a substantial influx of leukocytes into the dominant follicle. Despite this, the precise impact of leukocytes on the ovulatory process remains largely uncharted territory. This knowledge gap serves as the foundation of the proposed study, which endeavors to elucidate the role of leukocytes in facilitating ovulation and luteinization in the human ovary. Our preliminary findings, derived from single-cell RNA sequencing (scRNA-seq) analysis using follicular aspirates obtained from in vitro fertilization…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.