NIH R01 · 2025
Study of alcoholic ketoacidosis in mice
Summary Alcoholic ketoacidosis is a metabolic complication caused by chronic/binge alcohol drinking in a state of poor nutrition. Chronic alcohol use depletes glycogen stores in the liver and impairs gluconeogenesis, causing decreased glucose availability and increased reliance on fatty acid breakdown. This also alters counterregulatory hormone balance that further increases free fatty acid breakdown and ketone production, resulting in metabolic acidosis. The main features of alcoholic ketoacidosis are low blood bicarbonate levels, high ketone bodies, and high anion gaps. Alcoholic ketoacidosis commonly causes tachycardia, agitation, abdominal pain, nausea and vomiting, and it can lead to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.