NIH R01 · 2025
Radiographic markers and therapeutic targets of cerebral edema after SAH
PROJECT SUMMARY/ABSTRACT Subarachnoid Hemorrhage (SAH) is a type of hemorrhagic stroke that affects ~500,000 people annually world- wide and causes significant mortality and long-term disability. Severe cerebral edema (CE) occurs in ~30-40% of SAH and contributes to poor long-term outcomes. Although CE has been implicated as an important pathophysiologic process after SAH, CE targeted therapeutics have not been explored. In this proposal, we address important barriers to the development of therapies targeting CE by 1) using a Dual-energy CT (DECT) based method for measuring brain water content (BWC) to develop a validated measure of CE after SAH and 2) identifying the role of miR-335-3p and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.