NIH R01 · 2024
Spatiotemporal control of insulin signaling by mitotic regulators
SPECIFIC AIMS: Precise regulation of the insulin signaling pathway is critical for multiple facets of animal physiology 1-3. Dysregulation of the insulin signaling pathway has been linked to metabolic disorders, such as diabetes 4. As type 2 diabetes affects more than 400 million people worldwide 5, understanding the signaling pathways impacting this disease is of paramount importance. Genetic mutations of the insulin receptor (IR) cause rare and severe insulin resistance 6. Yet, the causes of insulin resistance seen in type 2 diabetes are numerous and the mechanisms are multifactorial leaving many unanswered questions. Upon insulin binding at the plasma membrane (PM), IR triggers the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.