NIH R01 · 2024
MRI-Based Quantitative Mapping of Oxygen Extraction Fraction in MS
PROJECT SUMMARY Multiple sclerosis (MS), one of the most common nontraumatic disabling neurological disorders, affects 309 per 100,000 adults in the United States, yet currently no cure exists. This is partly due to a lack of sensitive biomarkers for detecting disease-related changes, which impairs the development of effective treatments. One potential solution to this issue is to image oxygen extraction fraction (OEF), the ratio of oxygen a tissue extracts from the blood. As OEF directly quantifies tissue viability and functional activities, it can serve as a useful biomarker for better understanding, monitoring, and predicting prognosis of neurological disorders including MS. For…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.