NIH R01 · 2025
Acquisition and Consolidation of Contextual Fear Memory in Engram Cell Pathways
PROJECT SUMMARY/ABSTRACT In order to survive, animals develop fear responses to dangerous situations. The neural mechanism of learned fear has great survival value for animals, who must predict danger from seemingly neutral contexts. For adaptive fear, the brain discriminates between different contexts and associates only relevant contexts with aversive events. Dysregulation of this process leads to maladaptive overgeneralized fear in PTSD, which affects 7 percent of the U.S. population. A fundamental gap in understanding the mechanism underlying the specificity and persistence of contextual fear memory limits research on developing effective neuromodulatory strategies to prevent…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.