NIH R01 · 2024
Regulation of the host immune response to influenza by the checkpoint receptor Tim3
PROJECT SUMMARY Influenza remains an important cause of morbidity and mortality and current therapies have limited efficacy. Respiratory failure in influenza results from either prolonged viral replication or lung injury induced by an over exuberant immune response. It follows that a better understanding of the mechanisms that regulate the host immune response to IAV could lead to new therapies. Effector CD8+ T cells are responsible for clearance of influenza A virus (IAV) during primary infection but have also been implicated in immune- mediated lung injury. Effector CD8+ T cells also give rise to influenza-specific CD8+ tissue resident memory T cells (Trm), which mediate heterosubtypic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.