NIH R01 · 2025
Mechanisms regulating neutrophil proinflammatory activity in sepsis
Sepsis is the leading cause of death in intensive care units and often results in multiorgan failure caused by dysregulated immune responses to infection. There are over 700,000 sepsis cases in the U.S. annually, and approximately 250,000 people die as a result. Despite our understanding of the pathology of sepsis, the treatment options are limited. During sepsis, neutrophils are excessively recruited to the inflamed endothelium in multiple organs and contribute to tissue damage. Furthermore, proinflammatory neutrophils interact with platelets and form microthrombi, exacerbating thrombo-inflammatory conditions. Thus, the goals of this proposal are to understand the molecular mechanisms…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.