NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Immunotherapy can be highly effective against cancers that elicit some recognition from the immune system (e.g., melanoma), but it remains ineffectual against cancers that are largely invisible to immune detection (e.g., pancreatic cancer). Advances in cancer immunotherapy will require interventions that can make cancers more apparent to the immune system. A growing body of evidence suggests that focused ultrasound (FUS) tumor ablation could be that intervention. By non-invasively disrupting cancer cells, thermal and mechanical modes of FUS have been shown to trigger surprisingly potent immune responses against tumors. We have found that histotripsy, a non-thermal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.