NIH R01 · 2024
Nf2-dependent regulation of neuronal scaling in the developing cerebellum
Summary The production of different types of neurons in the appropriate proportions, called neuronal scaling, is critical for the formation of functional neural circuits and proper excitatory/inhibitory balance. Disruption of neuronal scaling contributes to the pathogenesis of developmental brain disorders, including spinocerebellar ataxia and autism. Although significant progress has been made toward understanding the differentiation of specific neurons, little is known regarding the mechanisms that scale the number of functionally related neurons in the brain. The cerebellum contains only few neuronal cell types, the developmental origins of which are well- established. Thus, the…
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