NIH R01 · 2024
Non-transcriptional regulation of circadian physiology
PROJECT SUMMARY Robust daily biological rhythms are key hallmarks of animal healthspan and are strongly regulated by circadian clocks. These cell-autonomous molecular timers enable animals to adapt to predictable daily changes in their environment. Clock-controlled outputs are all-encompassing and clock disruption is associated with a wide range of pathologies and chronic diseases. In the natural world, environmental signals, e.g. light and temperature, enable animal circadian clocks to control timing of food intake. Nutrient influx can therefore provide metabolic signals to reinforce environmental signals, promoting synchrony in cellular physiology to balance metabolism and energy use.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.