NIH R01 · 2024
Function and Regulation of the BCL-2 Family
PROJECT SUMMARY The impact of the mitochondrial pathway of apoptosis on cancer biology is broad because the BCL-2 (B-cell CLL/Lymphoma 2) family regulates tumor initiation and maintenance, and is directly targeted by anti- cancer therapies. Therefore, a mechanistic understanding of BCL-2 family function will advance our knowledge of the pathways that cause cancer, and are clinically targeted to cure cancer. The mitochondrial pathway of apoptosis proceeds when the BCL-2 family collaborates to compromise the outer mitochondrial membrane (OMM). This process, referred to as mitochondrial outer membrane permeabilization (MOMP), allows for pro- apoptotic factors within mitochondria to gain access…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.