NIH R01 · 2025
Heterochromatin Repair Mechanisms: a Chromatin Perspective
SUMMARY About 10-30% of human and fly genomes comprises pericentromeric heterochromatin, a poorly characterized component of the genome where defective repair of double-strand breaks (DSB) can trigger widespread aberrant recombination and genome instability. Previous studies identified specialized mechanisms for “safe” homologous recombination (HR) repair of heterochromatin, including a poorly understood role for “silent” chromatin marks. The chromatin state is also deeply reorganized in response to damage in heterochromatin, but little is known about the nature of these changes and their roles in repair. This lack of knowledge is a major barrier to understanding how misregulation of this…
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