NIH R01 · 2025
Biological basis of cardiac thick filament regulation
Project Summary Cardiac muscle contraction fundamentally relies on the activity of myosin to generate force. For a basic understanding of cardiac muscle contraction and to address the unmet needs in treating heart diseases, it is essential to elucidate the molecular mechanisms by which cardiac myosin and its regulatory partner, cardiac myosin-binding protein-C (cMyBP-C) modulate force generation. A disruption in the equilibrium between the structural states of cardiac myosin is known to cause altered energy consumption and impaired muscle contraction. Thus, manipulation of myosin structural states is a promising approach to treat cardiomyopathies. However, our understanding of the basic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.