NIH R01 · 2024
A CRISP(e)R approach to alleviating HIV-associated COPD
PROJECT SUMMARY People living with HIV demonstrate increased incidence of lung inflammation and HIV is an independent risk factor development of COPD. In the era of antiretroviral therapy (ART) with markedly improved life expectancy, lung related chronic conditions like COPD and bacterial pneumonia are primarily responsible for increased morbidity and mortality in people living with HIV (PLWH). HIV patients die of non-AIDS comorbidities almost a decade earlier that their non-HIV counterparts. Identifying the pathophysiological mechanism and treatment of HIV-associated comorbidities is very complex in chronic lung diseases, even with ART. TGF-β signaling upregulated by HIV Tat, and Tat…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.