Ching Lab

Washington University

ENGINEERING (ALL TYPES)

Saint Louis · United States

NIH-funded
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Research focus

NIH R01 · 2025

SCH: Mechanism-based dose titration for modifying brain electrophysiology during antidepressant therapy

Treatment-resistant depression (TRD) is a debilitating mental health condition in which patients experience persistent symptoms despite medical intervention, leading to adverse outcomes and an overall diminished quality of life. This condition imposes a significant financial burden on both individuals and healthcare systems due to frequent medical consultations, ongoing therapies, and lost productivity. TRD is typically defined by the failure to respond to at least two different classes of oral antidepressant medications, underscoring the critical need for new therapeutic approaches. One promising avenue for treating TRD and other neuropsychiatric disorders is the use of pharmacological…

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