NIH R01 · 2025
Mechanisms Underlying Takotsubo Syndrome
Our proposal tests the overarching hypothesis that regional differences in coronary regulation cause micro- areas of ischemia in the apex of the heart and induce Takotsubo Syndrome. We posit that the level of ischemia in the ballooning area is not sufficient to produce cell death, but enough of a decrease to invoke an adaptive program of “myocardial hibernation,” confined to area of ballooning, where the decrease in flow leads to a decrease in cardiac function. The consequence of apical hibernation is a restoration of the match between myocardial blood flow and function as the reduced apical function matches the lower myocardial blood flow, resolving the ischemia. The “benefit” of this…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.