Chien Lab

University of California Berkeley

ENGINEERING (ALL TYPES)

Berkeley · United States

NIH-funded
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NIH R01 · 2025

A CMOS-based miniaturized and disposable molecular detection system enabling sample in-situ biosensing

Project Summary Over the past two decades, point-of-care (POC) systems enabled detection of biomarkers at or near the patient, bypassing the need to transport samples to a centralized lab, thereby enabling rapid molecular diagnoses. A key innovation that enabled this technology is the integration of sample preparation processes into a miniaturized, disposable “lab-on-a-chip” device. However, most current POC systems still require an external instrument for automated processing and detection, increasing the system size, complexity, and cost. This makes such systems impractical for low-resource settings. To address this need, we propose a miniaturized, disposable CMOS-based POC system that…

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