Chien Lab

Research focus

NIH R01 · 2024

Investigation of arterial changes in the Circle of Willis during intracranial aneurysm growth in humans

PROJECT SUMMARY/ABSTRACT Prevalence of saccular intracranial aneurysms (IA) in western populations is estimated at around ~3%. Clinically, IA present a dilemma, in that they are usually asymptomatic; however, IA are extremely dangerous if they rupture, causing subarachnoid hemorrhage (~50% mortality). There is convincing evidence that continued IA growth increases the risk of rupture (12-24 times). To better monitor and predict IA progression, there is a compelling need to better understand clinical IA growth (aneurysmal remodeling). 90% of IA occur within the arteries of the Circle of Willis (CoW). Despite there being overwhelming evidence connecting CoW vascular remodeling and IA disease,…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.