NIH R01 · 2025
Mitochondrial NAD+ Metabolism in Cardiac Aging
Project Summary/Abstract Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor for energy metabolism and a co-substrate of sirtuins for protein deacetylation. Cellular NAD+ levels decline with age in the heart and other organs. Previous studies have shown that cellular NAD+ repletion or boosting is protective against aging and age-related diseases. NAD+ is compartmentalized at subcellular levels and the proper distribution of NAD+ into mitochondria is crucial for NAD+-dependent metabolic and signaling function in mitochondria. SLC25A51 was recently identified as the primary mammalian mitochondrial NAD+ (mtNAD+) transporter that imports NAD+ from cytosol into mitochondria. Unlike the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.