NIH R01 · 2024
PROJECT ABSTRACT/SUMMARY Alzheimer's disease (AD) is the most common cause of dementia. Beta-amyloid plaques in the brain on autopsy are one of the key pathological hallmarks of AD, but numerous clinical trials targeting beta-amyloid have failed. Many studies in brain specimens and animal models of AD have shown that iron is found in and adjacent to beta-amyloid plaques and may contribute to neuronal injury. People with evidence of beta-amyloid plaques on positron emission tomography (PET) and high levels of brain iron have accelerated cognitive decline. However, the mechanisms linking iron to cognitive decline in humans remain unclear. Elucidating these mechanisms is critical for the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.