NIH R01 · 2024
Functional interactions of cardiac ion channels
ABSTRACT Our laboratory was the first to demonstrate unequivocally that several isoforms of small conductance Ca2+- activated K+ channels (SK or KCa2 channels) underlie Ca2+-activated K+ current (IK,Ca) in cardiomyocytes. Since our original reports, knowledge of cardiac SK channels in the field has been greatly expanded. Studies by our group and more recently by others, have provided evidence to substantiate the important roles of SK channels in the heart. Interests in cardiac SK channels are further fueled by recent studies suggesting the possible roles of SK channels in human arrhythmias and atrial fibrillation (AF). Therefore, SK channel may represent a novel therapeutic target for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.