NIH R01 · 2025
Regulation of T cell memory in tissue immunity
Program Summary/Abstract Tissue-resident memory T cells (TRM) are crucial for the frontline defense against pathogen infection and maintenance of tissue homeostasis. How T cells are fated for TRM development and targeted for residency in specific tissue sites remain poorly understood. The environmental cues that orchestrate metabolic adaptation for TRM development or maintenance are also unclear. These knowledge gaps represent substantial barriers to harnessing the full therapeutic potential of TRM cells in infectious disease and cancer. In our preliminary studies, using in vivo pooled CRISPR screening of mitochondria and lysosome-associated genes, we uncovered organelle signaling and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.